Image

Epidemiology

1) Evaluating differences in prevention effectiveness of LLINs on Plasmodium infection and malaria disease incidence

2) Determining the relationships between intensity of pyrethroid insecticide resistance and incidence of Plasmodium infection and malaria disease

3) Characterizing the biting behavior of principal Anopheles vectors and relate to Plasmodium infection and malaria disease incidence




Understanding the factors affecting the effectiveness LLINs on malaria infection and disease: community-based studies

  • Two cohorts of ~950 children living within 5 km of either Namanolo or Ntaja Health Centers
  • Cleared of malaria infection at the time of enrolment
  • Outcomes: time to first malaria infection and incidence of malaria disease
  • Predictors: LLIN use, condition; socio-economic factors, house construction
  • Collect and rear mosquitoes from the field in the insectary at the Malaria Alert Centre
  • Determine levels of resistance using
    • WHO tube assays
    • CDC bottle assays
  • Compare malaria infection and disease rates in households with difference resistance patterns
  • Conduct human landing catch studies inside and outside sentinel households within the ICEMR study sites
    • Rainy season, dry season
    • 6:00 PM – 10:00 AM
  • Characterize caught mosquitoes
    • Species, sex
    • Blood fed or not
    • Potentially infectious to humans or not
  • Analyze patterns of human infection and disease in relation to the feeding behaviors

Investigators

Image

Don Mathanga M.D., Ph.D.  
Director of the COM-MACCDAC
Associate Professor
College of Medicine 

Image
Charles ManganiM.D., Ph.D.  
Assistant Professor of Epidemiology
College of Medicine of Blantyre
University of Malawi

Collaborators

Image

Mark Wilson, Sc.D.
Professor Emeritus
Department of Epidemiology
School of Public Health
University of Michigan

This is title

Image
Themba Mzilahowa, Ph.D.
Associate Professor
College of Medicine
University of Malawi
Image

Edward D. Walker, Ph.D.
Professor
Department of Microbiology and Molecular Genetrics
Michigan State University

Project Location

  • Balaka
  • Machinga

Project Duration

2018 - 2024

Project Publications

  1. Conn JE, Norris DE, Donnelly MJ, Beebe NW, Burkot TR, Coulibaly MB, Chery L, Eapen A, Keven JB, Kilama M, Kumar A, Lindsay SW, Moreno M, Quinones M, Reimer LJ, Russell TL, Smith DL, Thomas MB, Walker ED, Wilson ML, Yan G. Entomological Monitoring and Evaluation: Diverse Transmission Settings of ICEMR Projects Will Require Local and RegionalMalaria Elimination Strategies. Am J Trop Med Hyg. 2015 Aug 10. pii: 15-0009. https://pubmed.ncbi.nlm.nih.gov/26259942/

  2. Mathanga DP, Tembo AK, Mzilahowa T, Bauleni A, Mtimaukenena K, Taylor TE, Valim C, Walker ED, Wilson ML.of malaria risk in urban and peri-urban areas of Blantyre, Malawi. Malar J. 2016 Dec 8;15(1):590. PubMed PMID: 27931234; PubMed Central PMCID: PMC5146950 https://pubmed.ncbi.nlm.nih.gov/27931234/

  3. Mathanga DP, Walker ED, Wilson ML, Ali D, Taylor TE, Laufer MK. Malaria control in Malawi: Current status and directions for the future. Acta Trop 2012;121(3):212-7. PMID: 21763670 https://pubmed.ncbi.nlm.nih.gov/21763670/

  4. Moss WJ, Dorsey G, Mueller I, Laufer MK, Krogstad DJ, Vinetz JM, Guzman M, Rosas-Aguirre AM, Herrera S, Arevalo-Herrera M, Chery L, Kumar A, Mohapatra PK, Ramanathapuram L, Srivastava HC, Cui L, Zhou G, Parker DM, Nankabirwa J, Kazura JW; Malaria Epidemiology and Control Within the International Centers of Excellence for Malaria Research. Am J Trop Med Hyg. 2015 Sep;93(3 Suppl):5-15. https://pubmed.ncbi.nlm.nih.gov/26259946/

  5. Wilson ML, Walker ED, Mzilahowa T, Mathanga DP, Taylor TE. Malaria elimination in Malawi: Research needs in highly endemic, poverty-stricken contexts.  Acta Trop  2012;121(3):218-26.  PMID: 22100546 https://pubmed.ncbi.nlm.nih.gov/22100546/

  6. Wilson ML, Krogstad DJ, Arinaitwe E, Arevalo-Herrera M, Chery L, Ferreira MU, Ndiaye D, Mathanga DP, Eapen A. UrbanMalaria: Understanding its Epidemiology, Ecology, and Transmission Across Seven Diverse ICEMR Network Sites. Am J Trop Med Hyg. 2015 Sep;93(3 Suppl):110-23. PMID:26259941 https://pubmed.ncbi.nlm.nih.gov/26259941/

  7. Quiñones ML, Norris DE, Conn JE, Moreno M, Burkot TR, Bugoro H, Keven JB, Cooper R, Yan G, Rosas A, Palomino M, Donnelly MJ, Mawejje HD, Eapen A, Montgomery J, Coulibaly MB, Beier JC, Kumar A. Insecticide Resistance in Areas Under Investigation by the International Centers of Excellence for Malaria Research: A Challenge for Malaria Control and Elimination. Am J Trop Med Hyg 2015r;93(3 Suppl):69-78. PubMed PMID: 26259947; PubMed Central PMCID: PMC4574276. https://pubmed.ncbi.nlm.nih.gov/26259947/

  8. Dear NF, Kadangwe C, Mzilahowa T, Bauleni A, Mathanga DP, Duster C, Walker ED, Wilson ML. Household-level and surrounding peri-domestic environmental characteristics associated with malariavectors Anopheles arabiensis and Anopheles funestus along an urban-rural continuum in Blantyre, Malawi. Malar J. 2018;17(1):229. PMID: 29884176 https://pubmed.ncbi.nlm.nih.gov/29884176/

  9. Stanley CC, Kazembe LN, Mukaka M, Otwombe KN, Buchwald AG, Hudgens MG, Mathanga DP, LauferMK, Chirwa TF.  Systematic review of analytical methods applied to longitudinal studies of malaria. Malar J. 2019;18(1):254. PMID: 31357990 https://pubmed.ncbi.nlm.nih.gov/31357990/

  10. Stanley CC, Kazembe LN, Buchwald AG, Mukaka M, Mathanga DP, Hudgens MG, LauferMK, Chirwa TF. Joint modelling of time-to-clinical malaria and parasite count in a cohort in an endemic area. J Med Stat Inform. 2019;7. pii: 1. PMID: 31245015 https://pubmed.ncbi.nlm.nih.gov/31245015/